| - | Denison vs Centre (September 17, 2022) |
| Sarah Robertson (DENW) def. Ella Rueff (CENT) 6-0, 6-2 |
| Monique Brual (DENW) def. Grace Williams (CENT) 6-0, 6-1 |
| Caroline Lopez (DENW) def. Carlie Mitchell (CENT) 3-6, 6-2, 1-0 (10-2) |
| Peyton Oda (DENW) def. Kayla Harger (CENT) 6-1, 6-0 |
| Sofia Zafiropulos (DENW) def. Mamie Sevier (CENT) 6-1, 6-1 |
| Elizabeth Hoo (DENW) def. Abby Jamison (CENT) 6-0, 6-0 |
| Kennedy Herring (DENW) def. Sophie Maddux (CENT) 6-0, 6-1 |
| Anna Leach (DENW) def. Skylar Keesee (CENT) 6-2, 6-0 |
| - | Case vs Otterbein (September 17, 2022) |
| Radha Patel (CWR-W) def. Erin Storrer (OTT) 6-3, 6-1 |
| Katalina Wang (CWR-W) def. Lillia Walter (OTT) 6-1, 6-3 |
| Pallavi Goculdas (CWR-W) def. Emma Henson (OTT) 6-1, 6-4 |
| Elsa Syed (CWR-W) def. Rachelle Moses (OTT) 6-1, 6-1 |
| Caitlyn Hsu (CWR-W) def. Cassady Shough (OTT) 6-1, 6-2 |
| Chloe Ku (CWR-W) def. Aubrey McMahon (OTT) 6-0, 6-0 |
| Ellior Rose (CWR-W) def. Olivia Eckels (OTT) 6-2, 6-0 |
| - | Case vs Centre (September 17, 2022) |
| Hannah Kassaie (CWR-W) def. Ella Rueff (CENT) 6-2, 6-1 |
| Lily McCloskey (CWR-W) def. Lainey Hill (CENT) 5-7, 6-0, 1-0 (10-8) |
| Anna Kan (CWR-W) def. Carlie Mitchell (CENT) 6-2, 3-6, 1-0 (10-2) |
| Asha Shukla (CWR-W) def. Grace Williams (CENT) 6-2, 6-3 |
| Nina Hoog (CWR-W) def. Mamie Sevier (CENT) 6-0, 6-2 |
| Elsa Syed (CWR-W) def. Abby Jamison (CENT) 6-1, 6-1 |
| Chloe Ku (CWR-W) def. Kayla Harger (CENT) 6-0, 6-1 |
| Ellior Rose (CWR-W) def. Sophie Maddux (CENT) 6-0, 6-2 |
| - | Denison vs Otterbein (September 17, 2022) |
| Sydney Cianciola (DENW) def. Erin Storrer (OTT) 7-6 (7-3), 2-6, 1-0 (10-5) |
| Sarah Robertson (DENW) def. Lillia Walter (OTT) 6-2, 6-2 |
| Monique Brual (DENW) def. Emma Henson (OTT) 6-1, 6-3 |
| Caroline Lopez (DENW) def. Rachelle Moses (OTT) 6-1, 6-1 |
| Peyton Oda (DENW) def. Cassady Shough (OTT) 6-0, 6-3 |
| Elizabeth Hoo (DENW) def. Aubrey McMahon (OTT) 6-0, 6-1 |
| Kennedy Herring (DENW) def. Julia Gillin (OTT) 6-1, 6-1 |
| Anna Leach (DENW) def. Olivia Eckels (OTT) 6-0, 6-1 |
| Sophie Russell (DENW) def. Julia Gillin (OTT) 6-2, 6-2 |
| - | Denison vs Case (September 18, 2022) |
| Hannah Kassaie (CWR-W) def. Sydney Cianciola (DENW) 6-0, 6-2 |
| Sarah Robertson (DENW) def. Lily McCloskey (CWR-W) 6-7 (4-7), 6-4, 1-0 (11-9) |
| Radha Patel (CWR-W) def. Monique Brual (DENW) 6-2, 6-3 |
| Katalina Wang (CWR-W) def. Caroline Lopez (DENW) 6-1, 6-1 |
| Asha Shukla (CWR-W) def. Peyton Oda (DENW) 6-1, 6-3 |
| Pallavi Goculdas (CWR-W) def. Sofia Zafiropulos (DENW) 6-3, 6-2 |
| Elsa Syed (CWR-W) def. Elizabeth Hoo (DENW) 6-3, 6-0 |
| Caitlyn Hsu (CWR-W) def. Kennedy Herring (DENW) 6-1, 6-1 |
| Ellior Rose (CWR-W) def. Anna Leach (DENW) 7-5, 6-4 |
| - | Centre vs Otterbein (September 18, 2022) |
| Erin Storrer (OTT) def. Ella Rueff (CENT) 6-2, 6-2 |
| Lainey Hill (CENT) def. Lillia Walter (OTT) 6-2, 6-3 |
| Emma Henson (OTT) def. Grace Williams (CENT) 7-5, 6-4 |
| Rachelle Moses (OTT) def. Mamie Sevier (CENT) 2-6, 6-4, 1-0 (10-0) |
| Cassady Shough (OTT) def. Kayla Harger (CENT) 6-3, 1-6, 1-0 (10-7) |
| Aubrey McMahon (OTT) def. Sophie Maddux (CENT) 6-1, 6-4 |
| Abby Jamison (CENT) def. Julia Gillin (OTT) 6-1, 6-2 |
| Skylar Keesee (CENT) def. Olivia Eckels (OTT) 6-1, 5-7, 1-0 (10-7) |
